Toll-Like Receptor 7 Stimulation Promotes the Development of Atherosclerosis in Apolipoprotein E-Deficient Mice
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چکیده
منابع مشابه
Protective role for Toll-like receptor-9 in the development of atherosclerosis in apolipoprotein E-deficient mice.
OBJECTIVE Atherosclerosis is driven by inflammatory reactions that are shared with the innate immune system. Toll-like receptor-9 (TLR9) is an intracellular pattern recognition receptor of the innate immune system that is currently under clinical investigation as a therapeutic target in inflammatory diseases. Here, we investigated whether TLR9 has a role in the development of atherosclerosis in...
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AIMS Atherosclerosis is a chronic inflammatory disease regulated by immune mechanisms. CD69 is a cell surface receptor rapidly induced after leukocyte activation at sites of chronic inflammation. Genetic disruption of CD69 in the mouse aggravates collagen-induced arthritis (CIA), and partial depletion of CD69-expressing cells with anti-CD69 monoclonal antibody (mAb) prevents CIA development in ...
متن کاملIL-25 Inhibits Atherosclerosis Development in Apolipoprotein E Deficient Mice
OBJECTIVE IL-25 has been implicated in the initiation of type 2 immunity and in the protection against autoimmune inflammatory diseases. Recent studies have identified the novel innate lymphoid type 2 cells (ILC2s) as an IL-25 target cell population. The purpose of this study was to evaluate if IL-25 has any influence on atherosclerosis development in mice. METHODS AND RESULTS Administration ...
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ژورنال
عنوان ژورنال: International Heart Journal
سال: 2020
ISSN: 1349-2365,1349-3299
DOI: 10.1536/ihj.19-365